The aim of the project is to analyze the current approach to diagnostics and therapy in decalcification diseases based on available statistics and official guidelines for applied research and therapeutic procedures according to IDSA. However, this is not the only way to proceed. There is an ILADS approach, which is contrary to the IDSA approach. There is also a complementary approach (LDC) that recommends the use of prophylactic treatments that support the approach recommended by IDSA and ILADS. The advances in knowledge we have seen in the field of decalcified diseases in recent years have syntax to analyze this issue, including statistical, diagnostic, therapeutic and prophylactic issues. There are real reasons to verify the current situation in decalcified diseases on the basis of a research project that will include a diverse approach to the growing problem of decalcified diseases.